Immunogenetics and the mapping of immunological functions
Date
2022
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Academic Press
Abstract
Immunological functions and resistance to disease are under partial genetic control. Biomarkers associated with immune function and disease resistance can be used in genetic selection programs to enhance innate health in avian species as part of a comprehensive disease control program. This chapter reviews studies on selection for immunological responses. Statistical approaches to identify loci and genomic regions associated with immune response and disease resistance are described, along with the important concepts of linkage disequilibrium and population design. Strategies are given for the use of molecular data in genetic selection. Systems biology and functional genomic approaches to improve animal health, including next-generation sequencing and transgenic animals, are presented. Predictions are made about the next waves of “omics” research that will contribute to elucidation of the genetic control of immunological traits and disease resistance.
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This is a manuscript of a chapter published as Lamont, Susan J., Jack CM Dekkers, Anna Wolc, and Huaijun Zhou. "Immunogenetics and the mapping of immunological functions." Avian immunology (2022): 277-297. doi:https://doi.org/10.1016/B978-0-12-818708-1.00011-7.