Synthesis of novel 6-deoxyanthracyclines
Date
1985-09-01
Authors
Hagen, Michael
Major Professor
Advisor
Committee Member
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
An extremely direct route to the 6-deoxyanthracycline skeleton is described. The initial route to quinone 10 failed due to an unexpected complication in the Ago demethylation step. However, starting from 2-bromo- 1,4-dimethoxynaphthalene, furan 17 could be prepared in two steps. Furan 17 was then converted into anthraquinone 19 in five steps. The eight-step route proceeds in 9% overall yield.
Series Number
Journal Issue
Is Version Of
Versions
Series
Academic or Administrative Unit
Type
article
Comments
Reprinted (adapted) with permission from The Journal of Organic Chemistry, 50(18); 3252-3255. Doi: 10.1021/jo00218a002. Copyright 1985 American Chemical Society.
Rights Statement
Copyright
Tue Jan 01 00:00:00 UTC 1985