High-molecular weight compounds of nitrogen and sulfur as therapeutic agents

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1946
Authors
Massie, Samuel
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Chemistry
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Chemistry
Abstract

General reviews of the chemotherapy of malaria and tuberculosis have been made;A survey of the physiological properties and therapeutic uses of compounds containing high-molecular weight aliphatic groups has been given;The large amount of lipoidal tissue present in certain strains of bacteria, such as the tubercle bacillus, suggested that the introduction into potential physiologically-active structures of groups which would be lipoidal-soluble might give rise to valuable medicinals. This thought initiated the study and preparation of nitrogen and sulfur compounds containing high-molecular weight aliphatic groups as therapeutic agents;Several nitrogen derivatives have been made for therapeutic testing, These agents include dibutylalkylamines derivatives of tetradecylamine and hexadecylamine. Rearrangement has been shown to occur during the reaction between alpha-halogenonaphthalenes and lithium dialkylamides, beta-dialkylaminonaphthalenes being formed;Several sulfur derivatives containing high-molecular weight aliphatic groups have been prepared for pharmacological testing. These compounds include quinolyl dodecyl sulfides, hydroxy sulfides, imidosulfides and sulfur-containing mercurials;The reaction between laurophenone and phosphorus pentachloride has been shown to give 1-phenyl-1-chlorododeceno-1 in good yield;Several miscellaneous compounds have been prepared for physiological testing. These compounds include anils derived from 1-diethylamino-4-aminopentane, substituted cinchoninic acids and phenothiazine derivatives;Complete pharmacological results are not available, but none of the commands on which reports have been received has shown any significant therapeutic activity.

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