Modern plant metabolomics: advanced natural product gene discoveries, improved technologies, and future prospects

dc.contributor.author Sumner, Lloyd W.
dc.contributor.author Lei, Zhentian
dc.contributor.author Nikolau, Basil
dc.contributor.author Saito, Kazuki
dc.contributor.department Biochemistry, Biophysics and Molecular Biology
dc.contributor.department Ames Laboratory
dc.date.accessioned 2022-03-23T16:44:33Z
dc.date.available 2022-03-23T16:44:33Z
dc.date.issued 2015
dc.description.abstract Plant metabolomics has matured and modern plant metabolomics has accelerated gene discoveries and the elucidation of a variety of plant natural product biosynthetic pathways. This review highlights specific examples of the discovery and characterization of novel genes and enzymes associated with the biosynthesis of natural products such as flavonoids, glucosinolates, terpenoids, and alkaloids. Additional examples of the integration of metabolomics with genome-based functional characterizations of plant natural products that are important to modern pharmaceutical technology are also reviewed. This article also provides a substantial review of recent technical advances in mass spectrometry imaging, nuclear magnetic resonance imaging, integrated LC-MS-SPE-NMR for metabolite identifications, and x-ray crystallography of microgram quantities for structural determinations. The review closes with a discussion on the future prospects of metabolomics related to crop species and herbal medicine.
dc.description.comments This is a manuscript of an article published as Sumner, Lloyd W., Zhentian Lei, Basil J. Nikolau, and Kazuki Saito. "Modern plant metabolomics: advanced natural product gene discoveries, improved technologies, and future prospects." Natural product reports 32, no. 2 (2015): 212-229. doi:10.1039/C4NP00072B. Posted with permission.
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/5w5pmejz
dc.language.iso en
dc.publisher © The Royal Society of Chemistry 2015
dc.source.uri https://doi.org/10.1039/c4np00072b *
dc.title Modern plant metabolomics: advanced natural product gene discoveries, improved technologies, and future prospects
dc.type Article
dspace.entity.type Publication
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relation.isOrgUnitOfPublication 25913818-6714-4be5-89a6-f70c8facdf7e
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