A Multi-Stimuli Responsive Alginate Nanogel for Anticancer Chemo-Photodynamic Therapy
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2023-03-27
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Elsevier B.V.
Abstract
Stimuli-responsive nanosystems enable highly effective targeting and therapeutic functions, including chemotherapy and photodynamic therapy (PDT). Traditional PDT alone cannot effectively eradicate the tumor burden; combined with chemotherapy, this combination presents a powerful treatment modality to modulate the tumor microenvironment (TME). Herein, we report a multi-stimulus responsive alginate nanogel that responds to the change in pH and redox potential in the TME. We coupled oxidized alginate with 4-mercapto phenylboronic acid and pheophorbide-a (a hydrophobic photosensitizer) and conjugated with adipic acid dihydrazide to design the nanogels. Further, we encapsulated doxorubicin, a cytotoxic agent, in the nanogel to enable chemotherapy. The alginate nanogel exhibited the pH-sensitive release of both pheophorbide-a and doxorubicin and simultaneously reduced the redox potential that enhanced PDT by increasing reactive oxygen species production. Our results demonstrate that the multi-stimuli responsive alginate nanogel enhances toxicity in breast cancer and melanoma.
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This is a manuscript of an article published as Pillarisetti, Shameer, Veena Vijayan, Jayakumar Rangasamy, Rizia Bardhan, Saji Uthaman, and In-Kyu Park. "A Multi-Stimuli Responsive Alginate Nanogel for Anticancer Chemo-Photodynamic Therapy." Journal of Industrial and Engineering Chemistry (2023).
DOI: 10.1016/j.jiec.2023.03.053.
Copyright 2023 The Korean Society of Industrial and Engineering Chemistry.
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0).
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