Use of Terbinafine in the Treatment Protocol of Intestinal Cryptococcus neoformans in a Dog

dc.contributor.author Olsen, Gavin
dc.contributor.author Deitz, Krysta
dc.contributor.author Flaherty, Heather
dc.contributor.author Haynes, Joseph
dc.contributor.author Lockhart, Shawn
dc.contributor.author Hurst, Steven
dc.contributor.author Haynes, Joseph
dc.contributor.department Veterinary Pathology
dc.contributor.department Veterinary Clinical Sciences
dc.date 2018-02-18T23:37:17.000
dc.date.accessioned 2020-07-07T05:16:16Z
dc.date.available 2020-07-07T05:16:16Z
dc.date.issued 2012-01-01
dc.description.abstract <p>A 2.5 yr old sexually intact male vizsla was admitted to the Iowa State University Veterinary Teaching Hospital for persistent diarrhea, weight loss, and panhypoproteinemia. Examination revealed an emaciated condition and melena. Two masses were palpated in the cranial abdomen. Hematology and serum biochemistry exhibited a regenerative anemia and confirmed the presence of panhypoproteinemia, suggestive of a protein-losing eneteropathy. Distinct areas of thickened intestinal wall and enlarged mesenteric lymph nodes were found on abdominal ultrasound. Cytology from those nodes showed the presence of suspected Cryptococcus spp., and infection was confirmed utilizing a cryptococcal antigen titer. Medical therapy with lipid-complexed amphotericin B and fluconazole was unsuccessful. Two surgical procedures were performed to remove the affected areas of intestine and lymph nodes, but the disease persisted as evidenced by a persistently elevated cryptococcal antigen titer. Terbinafine was prescribed, which resulted in complete resolution of clinical signs and a steadily decreasing cryptococcal antigen titer. Very few cases of intestinal cryptococcosis have been reported. In this case, infection resulted in a protein-losing enteropathy. In addition, this article describes the use of terbinafine in the treatment of intestinal cryptococcal infection in the dog, which has not been previously reported.</p>
dc.description.comments <p>This article is published as Olsen, Gavin L., Krysta L. Deitz, Heather A. Flaherty, Shawn R. Lockhart, Steven F. Hurst, and Joseph S. Haynes. "Use of terbinafine in the treatment protocol of intestinal Cryptococcus neoformans in a dog." Journal of the American Animal Hospital Association 48, no. 3 (2012): 216-220. <a href="http://dx.doi.org/10.5326" target="_blank">10.5326/JAAHA-MS-5813</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vpath_pubs/98/
dc.identifier.articleid 1101
dc.identifier.contextkey 10879867
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vpath_pubs/98
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92528
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vpath_pubs/98/2012_Haynes_UseTerbinafine.pdf|||Sat Jan 15 02:37:58 UTC 2022
dc.source.uri 10.5326/JAAHA-MS-5813
dc.subject.disciplines Small or Companion Animal Medicine
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.title Use of Terbinafine in the Treatment Protocol of Intestinal Cryptococcus neoformans in a Dog
dc.type article
dc.type.genre article
dspace.entity.type Publication
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