Lack of effect of a topical regenerative agent on re-epithelialization rate of canine spontaneous chronic corneal epithelial defects: A randomized, double-masked, placebo-controlled study

Date
2018-03-01
Authors
Sebbag, Lionel
Sebbag, Lionel
Allbaugh, Rachel
Strong, Travis
Allbaugh, Rachel
Strauss, Rachel
Wehrman, Rita
Foote, Braidee
Peterson, Chimene
Ben-Shlomo, Gil
Major Professor
Advisor
Committee Member
Journal Title
Journal ISSN
Volume Title
Publisher
Altmetrics
Authors
Research Projects
Organizational Units
Veterinary Clinical Sciences
Organizational Unit
Journal Issue
Series
Department
Veterinary Clinical Sciences
Abstract

Spontaneous chronic corneal epithelial defects (SCCEDs) are characteristic ulcers in dogs that are refractory to healing. The aim of the study was to evaluate the use of a topical regenerative agent to promote healing of SCCEDs. Nineteen dogs (20 eyes) were randomized to receive either regenerative agent (10 eyes) or placebo (10 eyes) every 48 h following corneal debridement, which was repeated 1 week later if the SCCED had not yet healed. The mean ± standard deviation time to re-epithelialization was 17.3 ± 12.8 days for the group treated with a topical regenerative agent and 19.3 ± 11.7 days for the group treated with a placebo; the cumulative healing rates were not statistically different (P > 0.650). A positive association was found between the initial size of the ulcer and the time to re-epithelialization (r = 0.555, P = 0.011). Although well tolerated by dogs, there was no therapeutic advantage in using a topical regenerative agent for re-epithelialization of SCCEDs.

Comments

This is a manuscript of an article published as Sebbag, L., R. Allbaugh, T. Strong, R. Strauss, R. Wehrman, B. Foote, C. Peterson, and G. Ben-Shlomo. "Lack of effect of a topical regenerative agent on re-epithelialization rate of canine spontaneous chronic corneal epithelial defects: A randomized, double-masked, placebo-controlled study." The Veterinary Journal 233 (2018): 63-65. DOI: 10.1016/j.tvjl.2018.01.003. Posted with permission.

Description
Keywords
Citation
DOI
Collections