The aim of this study has been to investigate the possible interaction between infections with Salmonella enterica serovar Typhimurium (S. Typhimurium) and Oesophagostomum spp. In an experimental set-up, groups of 10 pigs were infected with A) a mixture of O. dentatum and O. quadrispinulatum; B) O. dentatum, O. quadrispinulatum and S. Typhimurium, and C) S. Typhimurium only. Our study suggests that Oesophagostomum spp. infection in pigs provides the basis for a prolonged and intensified S. Typhimurium infection. Both levels and number of S. Typhimurium excreting pigs per day were significantly higher in the group with both Oesophagostomum spp. and S. Typhimurium infection compared to the group infected with S. Typhimurium only. Post mortem examinations paralleled these findings and demonstrated higher occurrence ofS. Typhimurium in pigs with concurrent parasite infection compared to pigs infected with S. Typhimurium only. An effect of the S. Typhimurium infection on the Oesophagostomum infection was not observed.