The aim of this study was to test the effectiveness of administering a select nitrocompound (S-NO) on reducing naturally colonized Campylobacter and experimentally infected Salmonella in the weaned pig gut. Pigs were divided into four groups; control (0 g S-NO/pig), 1X (0.2 g S-NO/pig), 5X (1 g S-NO/pig), and 10X (2 g S-NO/pig). Treatments were administered via oral gavage 24 h before sacrifice. Mean ± SD populations (log10 cfu/g) of Campylobacter in the cecum were reduced (P < 0.05) in pigs receiving the 10X dose when compared with untreated controls (1.64 ± 1.30 vs 5.31 ± 0.58, respectively). Campylobacter concentrations in rectal contents from pigs administered the 5X dose were reduced (P < 0.05) compared to control (2.65 ± 2.86 vs 5.90 ± 0.94, respectively). Rectal Salmonella concentrations were reduced (P < 0.05) in all of the S-NO-treated groups. Adverse effects of S-NO on pig health were not observed. These results demonstrate that S-NO may have potential as an intervention to reduce pig colonization by Campylobacter and Salmonella.