Sex differences in the cerebral BOLD signal response to painful heat stimuli

dc.contributor.author Moulton, Eric
dc.contributor.author Keaser, Michael
dc.contributor.author Gullapalli, Rao
dc.contributor.author Maitra, Ranjan
dc.contributor.author Greenspan, Joel
dc.contributor.department Statistics
dc.date 2019-06-27T09:38:33.000
dc.date.accessioned 2020-07-02T06:56:54Z
dc.date.available 2020-07-02T06:56:54Z
dc.date.copyright Sun Jan 01 00:00:00 UTC 2006
dc.date.issued 2006-08-01
dc.description.abstract <p>There are limited data addressing the question of sex differences in pain-related cerebral processing. This study examined whether pain-related blood oxygenation level-dependent (BOLD) signal change measured with functional magnetic resonance imaging (fMRI) demonstrated sex differences, under conditions of equivalent pain perception. Twenty-eight healthy volunteers (17 women, 11 men) were subject to a fMRI scan while noxious heat stimuli were applied to the dorsum of the left foot. Significant BOLD signal modulation was observed in several nociceptive processing regions of interest (ROIs) in all subjects. There were no sex differences in the spatial extent of BOLD signal change for any ROI, but the signal amplitude was lower for women in most ROIs and significantly so for the primary somatosensory cortex (S1), the midanterior cingulate cortex, and the dorsolateral prefrontal cortex (DLPFC). The BOLD signal response could be positive or negative, and frequently, both polarities were observed within a single ROI. In most ROIs, women show proportionately more voxels with negative signal change than men, and this difference was statistically significant for the S1 and the DLPFC. The time course of the negative signal change was very similar to that of the positive signal change, suggesting that the latter was not “driving” the former. The location of negative and positive clusters formed distinct patterns in several of the ROIs, and these patterns suggest something other than a local “steal” phenomenon as an explanation for the negative signal changes. Sex differences in baseline cerebral blood flow may contribute to the BOLD signal differences observed in this study.</p>
dc.description.comments <p>This is a manuscript of an article published as Moulton, Eric A., Michael L. Keaser, Rao P. Gullapalli, Ranjan Maitra, and Joel D. Greenspan. "Sex differences in the cerebral BOLD signal response to painful heat stimuli." <em>American Journal of Physiology-Regulatory, Integrative and Comparative Physiology</em> 291, no. 2 (2006): R257-R267. DOI: <a href="http://dx.doi.org/10.1152/ajpregu.00084.2006" target="_blank">10.1152/ajpregu.00084.2006</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/stat_las_pubs/163/
dc.identifier.articleid 1172
dc.identifier.contextkey 14423985
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath stat_las_pubs/163
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/90469
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/stat_las_pubs/163/2006_MaitraRanjan_SexDifferences.pdf|||Fri Jan 14 20:58:07 UTC 2022
dc.source.uri 10.1152/ajpregu.00084.2006
dc.subject.disciplines Analytical, Diagnostic and Therapeutic Techniques and Equipment
dc.subject.disciplines Applied Statistics
dc.subject.keywords nociception
dc.subject.keywords fMRI
dc.subject.keywords somatosensory cortex
dc.subject.keywords neuroimaging
dc.subject.keywords prefrontal cortex
dc.subject.keywords negative BOLD signal
dc.title Sex differences in the cerebral BOLD signal response to painful heat stimuli
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isOrgUnitOfPublication 264904d9-9e66-4169-8e11-034e537ddbca
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