Cobalt-catalyzed hydroacylation of N-Vinylindole

Abstract

<p>One route to keeping costs low in the pharmaceutical industry is to utilize cost effective materials for active catalyst systems. This research investigated intramolecular, enantioselective, hydroacylation of 1-(1- phenylvinyl)-1H-indole-2-carbaldehyde using cobalt catalysts to generate 3-phenyl-2,3-dihydro-1H-pyrrolo[1,2- a]indol-1-one. Cobalt has been shown to be a complimentary catalyst to rhodium in olefin hydroacylation. The reaction to generate 3-phenyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-one from 1-(1-phenylvinyl)-1H-indole-2- carbaldehyde has been demonstrated using rhodium catalysis. We used commercially available cobalt(II) precursors, phosphine ligands, and reductants in attempts to generate an active catalyst system for olefin hydroacylation</p>