Subsurface agricultural drainage has allowed for enhanced crop production in many areas of the world including the upper Midwest, United States. However, the presence of nitrate-nitrogen (nitrate-N) in subsurface tile drainage water is a topic of intense scrutiny due to several water quality issues. Many studies have been conducted looking at ways to reduce nitrate-N in tile drainage (Baker et al., 1975; Baker and Johnson, 1981; Hanway and Laflen, 1974; Kanwar et al., 1988).With the growing concern for the health of the Gulf of Mexico (Mitsch et al., 2001; Rabalais et al., 1996) and local water quality concerns, there is a need to understand how recommended nitrogen management practices, such as through nitrogen rate and timing, impact nitrate-N concentrations from subsurface drainage systems. The objective of this paper is to summarize results of studies from within Iowa and nearby states that have documented the impact of nitrogen application rate and timing on tile drainage nitrate loss.