Immunosenescence and its influence on reproduction in a long-lived vertebrate

dc.contributor.author Judson, Jessica
dc.contributor.author Reding, Dawn
dc.contributor.author Bronikowski, Anne
dc.contributor.author Bronikowski, Anne
dc.contributor.department Ecology, Evolution and Organismal Biology
dc.date 2020-05-11T16:37:59.000
dc.date.accessioned 2020-06-30T02:18:43Z
dc.date.available 2020-06-30T02:18:43Z
dc.date.copyright Wed Jan 01 00:00:00 UTC 2020
dc.date.embargo 2021-05-06
dc.date.issued 2020-05-06
dc.description.abstract <p>Immunosenescence is a well-known phenomenon in mammal systems, but its relevance in other long-lived vertebrates is less understood. Further, the influence of age and reproductive effort on immune function in long-lived species can be challenging to assess, as long-term data are scarce and it is often difficult to sample the oldest age classes. We used the painted turtle (<em>Chrysemys picta</em>) to test hypotheses of immunosenescence and a trade-off between reproductive output and immune function in a population of a long-lived vertebrate that has been monitored for over 30 years. These long-term data are utilized to employ a unique approach of aging turtles with mark-recapture data and population-specific growth modeling to obtain more accurate estimates of age. We analyzed natural antibodies, lysis ability, and bactericidal competence in 126 individuals from 1 to 33 years of age captured during May and June in 2011. Older turtles exhibited greater natural antibody levels than young individuals across sexes. Young females with large clutches exhibited greater lysis ability, while older females with large clutches had decreased lysis ability, suggesting a trade-off between reproductive output and immune function conditional upon age. However, bactericidal competence increased later in the nesting season for older females. Our study rejects the hypothesis of immunosenescence in a long-lived turtle, despite evidence of actuarial and reproductive senescence in this population. Additionally, we detected mixed evidence for a trade-off between reproduction and immune health.</p>
dc.description.comments <p>This is a manuscript of an article published as Judson, Jessica M., Dawn M. Reding, and Anne M. Bronikowski. "Immunosenescence and its influence on reproduction in a long-lived vertebrate." <em>Journal of Experimental Biology</em> (2020). doi: <a href="https://doi.org/10.1242/jeb.223057" target="_blank">10.1242/jeb.223057</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/eeob_ag_pubs/401/
dc.identifier.articleid 1407
dc.identifier.contextkey 17699749
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath eeob_ag_pubs/401
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/23287
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/eeob_ag_pubs/401/2020_Bronikowski_ImmunosenescenceInfluenceManuscript.pdf|||Sat Jan 15 00:07:57 UTC 2022
dc.source.uri 10.1242/jeb.223057
dc.subject.disciplines Animal Sciences
dc.subject.disciplines Ecology and Evolutionary Biology
dc.subject.disciplines Immunity
dc.subject.disciplines Longitudinal Data Analysis and Time Series
dc.subject.keywords Immune function
dc.subject.keywords reptile
dc.subject.keywords senescence
dc.subject.keywords sex-specific
dc.title Immunosenescence and its influence on reproduction in a long-lived vertebrate
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 67b6be17-6fb6-4241-86a2-464dbd5c5e58
relation.isOrgUnitOfPublication 6fa4d3a0-d4c9-4940-945f-9e5923aed691
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