Bitter Compounds Decrease Gastric Emptying and Influence Intestinal Nutrient Transport

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dc.contributor.author Mani, Venkatesh
dc.contributor.author Hollis, James
dc.contributor.author Hollis, James
dc.contributor.author Gabler, Nicholas
dc.date 2018-08-25T20:22:44.000
dc.date.accessioned 2020-06-29T23:34:02Z
dc.date.available 2020-06-29T23:34:02Z
dc.date.copyright Sun Jan 01 00:00:00 UTC 2012
dc.date.issued 2012-01-01
dc.description.abstract <p>The effect of bitter tasting compounds on gastric emptying and nutrient transport from the intestine was studied using in vivo and ex vivo models. Sixteen pigs were fed a diet containing the bitter compound phenylthiocarbamide (PTC). The animals were euthanized 45 minutes postprandially and gastric contents were measured to quantify the gastric retention. Additionally, freshly isolated small intestines were mounted into modified Ussing chambers to study the effects of PTC on ex vivo nutrient transport. In summary, bitter compounds decreased the gastric emptying in vivo and increased the nutrient transport ex vivo. Further, cell culture studies identified that bitter compounds might exert their action through stimulating the secretion of the intestinal hormone cholecystokinin (CCK) from the enteroendocrine cells by increasing the intracellular calcium concentrations. Altogether, these data suggest that bitter compounds regulate feed intake and nutrient transport.</p>
dc.identifier archive/lib.dr.iastate.edu/ans_air/vol658/iss1/57/
dc.identifier.articleid 1763
dc.identifier.contextkey 3410193
dc.identifier.doi https://doi.org/10.31274/ans_air-180814-941
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ans_air/vol658/iss1/57
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/8896
dc.language.iso en
dc.relation.ispartofseries Animal Science Research Reports
dc.relation.ispartofseries ASL R2725
dc.source.bitstream archive/lib.dr.iastate.edu/ans_air/vol658/iss1/57/R2725.pdf|||Sat Jan 15 00:58:29 UTC 2022
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Sciences
dc.subject.keywords ASL R2725
dc.title Bitter Compounds Decrease Gastric Emptying and Influence Intestinal Nutrient Transport
dc.type article
dc.type.genre swine
dspace.entity.type Publication
relation.isAuthorOfPublication 7dadf17d-615c-4ee6-887a-c7827df4950b
relation.isJournalIssueOfPublication 6dc63976-6a4a-4b75-a79f-e40937b79e61
relation.isSeriesOfPublication 7f3839b7-b833-4418-a6fa-adda2b23950a
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