Effect of variation in oxytetracycline treatment of Lawsonia intracellularis diahrea in nursery pigs on treatment-efficacy and resistance development

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2015-01-01
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Larsen, I.
Mellerup, A.
Zachariasen, C.
Saxmose Nielsen, S.
Folkesson, A.
Angen, Ø.
Christiansen, L.
Græsbøl, K.
Damborg, P.
Nielsen, J.
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International Conference on the Epidemiology and Control of Biological, Chemical and Physical Hazards in Pigs and Pork
Iowa State University Conferences and Symposia

The SafePork conference series began in 1996 to bring together international researchers, industry, and government agencies to discuss current Salmonella research and identify research needs pertaining to both pig and pork production. In subsequent years topics of research presented at these conferences expanded to include other chemical and biological hazards to pig and pork production.

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A Danish research project, MINIRESIST, investigated the consequences of varying doses and treatment strategies for oxytetracycline treatment of Lawsonia intracellularis diarrhea in nursery pigs. Batches of nursery pigs in five herds were randomly allocated to one of five treatment protocols (batch treatment orally with high, normal and low doses; penwise treatment with normal dose and injection treatment with normal dose). Outcomes, in terms of reduction of L. intracellularis determined by qPCR, growth rate and fecal dry matter content (determined on 30 pigs per batch in 61 batches), and levels of tetracyclineresistant coliforms, and quantification of resistance genes in intestinal content (determined on 15 pigs per batch in 80 batches), were determined and analyzed statistically.

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Thu Jan 01 00:00:00 UTC 2015