Conversion of lactones into ethers

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1981-05-01
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Frazier, Kevin
Roth, Bruce
Taschner, Michael
Neuenschwander, Kent
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Kraus, George
University Professor Emeritus
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Chemistry

The Department of Chemistry seeks to provide students with a foundation in the fundamentals and application of chemical theories and processes of the lab. Thus prepared they me pursue careers as teachers, industry supervisors, or research chemists in a variety of domains (governmental, academic, etc).

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The Department of Chemistry was founded in 1880.

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1880-present

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Abstract

Although tetrahydrofurans and tetrahydropyrans are important structural subunits of many classes of natural products,l comparatively few general synthetic methods are known? Since y- and &lactones are readily available: an efficient and versatile transformation to the ether would significantly extend current methodology. The conversion of a lactone to an ether has been accomplished by hydride reduction to a diol followed by cyclization by way of a monotosylate4 or other activated ester.5

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Reprinted (adapted) with permission from The Journal of Organic Chemistry, 46(11); 2414-2419. Doi: 10.1021/jo00324a050. Copyright 1981 American Chemical Society.

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Thu Jan 01 00:00:00 UTC 1981
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