The Maize Unstable factor for orange1 Is a Dominant Epigenetic Modifier of a Tissue Specifically Silent Allele of pericarp color1 Chopra, Surinder Cocciolone, Suzy Bushman, Shaun Sangar, Vineet McMullen, Michael Peterson, Thomas
dc.contributor.department Zoology
dc.contributor.department Agronomy 2018-02-18T10:48:45.000 2020-07-07T05:16:56Z 2020-07-07T05:16:56Z 2003-03-01
dc.description.abstract <p>We have characterized <em>Unstable factor for orange1</em> (<em>Ufo1</em>), a dominant, allele-specific modifier of expression of the maize <em>pericarp color1</em> (<em>p1</em>) gene. The <em>p1</em> gene encodes an <em>Myb</em>-homologous transcriptional activator of genes required for biosynthesis of red phlobaphene pigments. The <em>P1-wr</em> allele specifies colorless kernel pericarp and red cobs, whereas <em>Ufo1</em> modifies <em>P1-wr</em> expression to confer pigmentation in kernel pericarp, as well as vegetative tissues, which normally do not accumulate significant amounts of phlobaphene pigments. In the presence of <em>Ufo1, P1-wr</em> transcript levels and transcription rate are increased in kernel pericarp. The <em>P1-wr</em> allele contains approximately six <em>p1</em> gene copies present in a hypermethylated and multicopy tandem array. In <em>P1-wr Ufo1</em> plants, methylation of <em>P1-wr</em> DNA sequences is reduced, whereas the methylation state of other repetitive genomic sequences was not detectably affected. The phenotypes produced by the interaction of <em>P1-wr</em> and <em>Ufo1</em> are unstable, exhibiting somatic mosaicism and variable penetrance. Moreover, the changes in <em>P1-wr</em> expression and methylation are not heritable: meiotic segregants that lack <em>Ufo1</em> revert to the normal <em>P1-wr</em> expression and methylation patterns. These results demonstrate the existence of a class of modifiers of gene expression whose effects are associated with transient changes in DNA methylation of specific loci.</p>
dc.description.comments <p>This article is from <em>Genetics </em>163 (2003): 1135.</p>
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dc.identifier archive/
dc.identifier.articleid 1040
dc.identifier.contextkey 10168773
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath zool_pubs/40
dc.language.iso en
dc.source.bitstream archive/|||Sat Jan 15 00:07:24 UTC 2022
dc.subject.disciplines Agronomy and Crop Sciences
dc.subject.disciplines Cell and Developmental Biology
dc.subject.disciplines Genetics and Genomics
dc.subject.disciplines Plant Breeding and Genetics
dc.title The Maize Unstable factor for orange1 Is a Dominant Epigenetic Modifier of a Tissue Specifically Silent Allele of pericarp color1
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication ce966761-2eda-46df-bdb8-30787bedf687
relation.isOrgUnitOfPublication fdd5c06c-bdbe-469c-a38e-51e664fece7a
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