Molecularly imprinted artificial esterases with highly specific active sites and precisely installed catalytic groups

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2018-01-01
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Hu, Lan
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Zhao, Yan
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Chemistry

The Department of Chemistry seeks to provide students with a foundation in the fundamentals and application of chemical theories and processes of the lab. Thus prepared they me pursue careers as teachers, industry supervisors, or research chemists in a variety of domains (governmental, academic, etc).

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The Department of Chemistry was founded in 1880.

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1880-present

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Abstract

A difficult challenge in synthetic enzymes is the creation of substrate-selective active sites with accurately positioned catalytic groups. Covalent molecular imprinting in cross-linked micelles afforded such active sites in protein-sized, water-soluble nanoparticle catalysts. Our method allowed a systematic tuning of the distance of the catalytic group to the bound substrate. The catalysts displayed enzyme-like kinetics and easily distinguished substrates with subtle structural differences.

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This is a manuscript of an article published as Hu, Lan, and Yan Zhao. "Molecularly imprinted artificial esterases with highly specific active sites and precisely installed catalytic groups." Organic & Biomolecular Chemistry 16, no. 31 (2018): 5580-5584. DOI: 10.1039/C8OB01584H. Posted with permission.

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Mon Jan 01 00:00:00 UTC 2018
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