High-Throughput Selective Capture of Single Circulating Tumor Cells by Dielectrophoresis at a Wireless Electrode Array

dc.contributor.author Anand, Robbyn
dc.contributor.author Li, Min
dc.contributor.author Anand, Robbyn
dc.contributor.department Chemistry
dc.date 2018-02-19T01:51:36.000
dc.date.accessioned 2020-06-30T01:15:59Z
dc.date.available 2020-06-30T01:15:59Z
dc.date.copyright Sun Jan 01 00:00:00 UTC 2017
dc.date.embargo 2018-06-13
dc.date.issued 2017-06-13
dc.description.abstract <p>We demonstrate continuous high-throughput selective capture of circulating tumor cells by dielectrophoresis at arrays of wireless electrodes (bipolar electrodes, BPEs). The use of BPEs removes the requirement of ohmic contact to individual array elements, thus enabling otherwise unattainable device formats. Capacitive charging of the electrical double layer at opposing ends of each BPE allows an AC electric field to be transmitted across the entire device. Here, two such designs are described and evaluated. In the first design, BPEs interconnect parallel microchannels. Pockets extruding from either side of the microchannels volumetrically control the number of cells captured at each BPE tip and enhance trapping. High-fidelity single-cell capture was achieved when the pocket dimensions were matched to those of the cells. A second, open design allows many non-targeted cells to pass through. These devices enable high-throughput capture of rare cells and single-cell analysis.</p>
dc.description.comments <p>This article is published as Li, Min, and Robbyn K. Anand. "High-throughput selective capture of single circulating tumor cells by dielectrophoresis at a wireless electrode array." Journal of the American Chemical Society (2017). <a href="http://dx.doi.org/10.1021" target="_blank">10.1021/jacs.7b03288</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/chem_pubs/1015/
dc.identifier.articleid 2016
dc.identifier.contextkey 11020885
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath chem_pubs/1015
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/14310
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/chem_pubs/1015/2017_Anand_HighThroughput.pdf|||Fri Jan 14 18:14:52 UTC 2022
dc.source.uri 10.1021/jacs.7b03288
dc.subject.disciplines Analytical, Diagnostic and Therapeutic Techniques and Equipment
dc.subject.disciplines Biochemistry
dc.subject.disciplines Chemistry
dc.subject.disciplines Radiochemistry
dc.title High-Throughput Selective Capture of Single Circulating Tumor Cells by Dielectrophoresis at a Wireless Electrode Array
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 696b9b21-6cf6-454a-a612-cb3955311528
relation.isOrgUnitOfPublication 42864f6e-7a3d-4be3-8b5a-0ae3c3830a11
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