Total Synthesis of Coriandrin

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Date
1994-08-01
Authors
Kraus, George
Ridgeway, James
Kraus, George
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Chemistry
Abstract

Coriandrin, an antiviral agent, has been synthesized in nine steps from diketone 3. The key steps in the synthesis include an eficient aromatization reaction using N-bromosuccinimide and a palladium-mediated coupling of a benzylic bromide with a vinyl stannane.

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Reprinted (adapted) with permission from The Journal of Organic Chemistry, 59(17); 4735-4737. Doi: 10.1021/jo00096a013. Copyright 1994 American Chemical Society.

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