Total Synthesis of Coriandrin
Is Version Of
Coriandrin, an antiviral agent, has been synthesized in nine steps from diketone 3. The key steps in the synthesis include an eficient aromatization reaction using N-bromosuccinimide and a palladium-mediated coupling of a benzylic bromide with a vinyl stannane.
Reprinted (adapted) with permission from The Journal of Organic Chemistry, 59(17); 4735-4737. Doi: 10.1021/jo00096a013. Copyright 1994 American Chemical Society.