Total Synthesis of Coriandrin
Coriandrin, an antiviral agent, has been synthesized in nine steps from diketone 3. The key steps in the synthesis include an eficient aromatization reaction using N-bromosuccinimide and a palladium-mediated coupling of a benzylic bromide with a vinyl stannane.
Reprinted (adapted) with permission from The Journal of Organic Chemistry, 59(17); 4735-4737. Doi: 10.1021/jo00096a013. Copyright 1994 American Chemical Society.