Cognition, function, and prevalent dementia in centenarians and near-centenarians: An individual participant data (IPD) meta-analysis of 18 studies
Date
2022-12-01
Authors
Leung, Yvonne
Barzilai, Nir
Batko-Szwaczka, Agnieszka
Beker, Nina
Boerner, Kathrin
Brayne, Carol
Brodaty, Henry
Cheung, Karen Siu-Lan
Corrada, María M.
Crawford, John D.
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Wiley Periodicals LLC on behalf of Alzheimer's Association
Abstract
Introduction
There are limited data on prevalence of dementia in centenarians and near-centenarians (C/NC), its determinants, and whether the risk of dementia continues to rise beyond 100.
Methods
Participant-level data were obtained from 18 community-based studies (N = 4427) in 11 countries that included individuals ≥95 years. A harmonization protocol was applied to cognitive and functional impairments, and a meta-analysis was performed.
Results
The mean age was 98.3 years (SD = 2.67); 79% were women. After adjusting for age, sex, and education, dementia prevalence was 53.2% in women and 45.5% in men, with risk continuing to increase with age. Education (OR 0.95;0.92–0.98) was protective, as was hypertension (odds ratio [OR] 0.51;0.35–0.74) in five studies. Dementia was not associated with diabetes, vision and hearing impairments, smoking, and body mass index (BMI).
Discussion
Among the exceptional old, dementia prevalence remains higher in the older participants. Education was protective against dementia, but other factors for dementia-free survival in C/NC remain to be understood.
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article
Comments
This article is published as Leung,Y., Atzmon, G., Barzilai,N., Batko-Szwaczka, A., Beker, N., l Brayne, C., Brodaty, H., Cheung, K. S.-L.,Corrada, M. M.,Crawford, J. D., Galbussera, A. A., Gao, T., Gondo, Y., Hagberg, B., Holstege, H., Hulsman, M., Ishioka, Y. L., Jopp, D., Kawas, C. H., Kaye, J., Kochan, N. A., Lau, B. H.-P., Lipnicki,D. M., Lo, J. W., Lucca, U., Makkar, S. R., Marcon, G., Marlow, T., Martin, P., ..etal (2023). Cognition, function and prevalent dementia in Centenarians and Near-Centenarians: an individual participant data (IPD) meta-analysis of 17 studies. Alzheimer’s & Dementia, 19, 2265–2275. https://doi.org/10.1002/alz.12828
© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.