Cloning of the complete gene for pig PIT-1 and analysis of PIT-1 protein function
dc.contributor.author | Yu, T.-P. | |
dc.contributor.author | Sun, H. | |
dc.contributor.author | Rothschild, Max | |
dc.contributor.author | Tuggle, C. | |
dc.date | 2018-02-13T00:27:05.000 | |
dc.date.accessioned | 2020-07-02T07:00:06Z | |
dc.date.available | 2020-07-02T07:00:06Z | |
dc.date.copyright | Thu Jan 01 00:00:00 UTC 1998 | |
dc.date.issued | 1998 | |
dc.description.abstract | <p>We have cloned and sequenced the complete proteincoding region of the pig PIT-1 gene. The pig PIT-1 gene is highly similar to the PIT-1 gene in other species (human, rodent, cattle). We also found some alternative forms of the pig PIT-1 gene. We have analyzed the protein function of the pig PIT-1 genes and one of its alternative forms; D3PIT-1. The functional studies showed that the pig PIT-1 protein can function normally at growth hormone (GH) and prolactin (PRL), whereas the pig D3PIT-1 protein cannot. These results imply that the pig PIT-1 gene is important in pig growth through regulation of GH and PRL gene expression, whereas its alternative forms might play different roles on PIT-1 target genes.</p> | |
dc.format.mimetype | application/pdf | |
dc.identifier | archive/lib.dr.iastate.edu/swinereports_1997/16/ | |
dc.identifier.articleid | 1015 | |
dc.identifier.contextkey | 3233628 | |
dc.identifier.s3bucket | isulib-bepress-aws-west | |
dc.identifier.submissionpath | swinereports_1997/16 | |
dc.identifier.uri | https://dr.lib.iastate.edu/handle/20.500.12876/91057 | |
dc.language.iso | en | |
dc.relation.ispartofseries | Animal Science Research Reports | |
dc.relation.ispartofseries | ASL R1492 | |
dc.source.bitstream | archive/lib.dr.iastate.edu/swinereports_1997/16/asl_1492.pdf|||Fri Jan 14 20:49:52 UTC 2022 | |
dc.subject.disciplines | Agriculture | |
dc.subject.disciplines | Animal Sciences | |
dc.subject.keywords | ASL R1492 | |
dc.title | Cloning of the complete gene for pig PIT-1 and analysis of PIT-1 protein function | |
dc.type | article | |
dc.type.genre | breeding_physiology | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | a5915699-0c8a-411e-a601-1564d7090ab9 | |
relation.isSeriesOfPublication | 7f3839b7-b833-4418-a6fa-adda2b23950a |
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