Cloning of the complete gene for pig PIT-1 and analysis of PIT-1 protein function

dc.contributor.author Yu, T.-P.
dc.contributor.author Sun, H.
dc.contributor.author Rothschild, Max
dc.contributor.author Tuggle, C.
dc.date 2018-02-13T00:27:05.000
dc.date.accessioned 2020-07-02T07:00:06Z
dc.date.available 2020-07-02T07:00:06Z
dc.date.copyright Thu Jan 01 00:00:00 UTC 1998
dc.date.issued 1998
dc.description.abstract <p>We have cloned and sequenced the complete proteincoding region of the pig PIT-1 gene. The pig PIT-1 gene is highly similar to the PIT-1 gene in other species (human, rodent, cattle). We also found some alternative forms of the pig PIT-1 gene. We have analyzed the protein function of the pig PIT-1 genes and one of its alternative forms; D3PIT-1. The functional studies showed that the pig PIT-1 protein can function normally at growth hormone (GH) and prolactin (PRL), whereas the pig D3PIT-1 protein cannot. These results imply that the pig PIT-1 gene is important in pig growth through regulation of GH and PRL gene expression, whereas its alternative forms might play different roles on PIT-1 target genes.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/swinereports_1997/16/
dc.identifier.articleid 1015
dc.identifier.contextkey 3233628
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath swinereports_1997/16
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/91057
dc.language.iso en
dc.relation.ispartofseries Animal Science Research Reports
dc.relation.ispartofseries ASL R1492
dc.source.bitstream archive/lib.dr.iastate.edu/swinereports_1997/16/asl_1492.pdf|||Fri Jan 14 20:49:52 UTC 2022
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Sciences
dc.subject.keywords ASL R1492
dc.title Cloning of the complete gene for pig PIT-1 and analysis of PIT-1 protein function
dc.type article
dc.type.genre breeding_physiology
dspace.entity.type Publication
relation.isAuthorOfPublication a5915699-0c8a-411e-a601-1564d7090ab9
relation.isSeriesOfPublication 7f3839b7-b833-4418-a6fa-adda2b23950a
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