New Alleles in the “RN gene” Associated with Low Glycogen Content in Pig Skeletal Muscle and Improved Meat Quality

dc.contributor.author Ciobanu, D.
dc.contributor.author Malek, M.
dc.contributor.author Rothschild, Max
dc.contributor.author Helm, J.
dc.contributor.author Woollard, J.
dc.contributor.author Rothschild, Max
dc.contributor.author Bastiaansen, J.
dc.contributor.author Plastow, G.
dc.date 2018-02-13T00:32:26.000
dc.date.accessioned 2020-07-02T07:01:27Z
dc.date.available 2020-07-02T07:01:27Z
dc.date.copyright Tue Jan 01 00:00:00 UTC 2002
dc.date.issued 2002-01-01
dc.description.abstract <p>Several quantitative trait loci (QTL) affecting muscle glycogen content and related meat quality traits were mapped to pig chromosome 15 (SSC 15) by using a three-generation intercross between Berkshire x Yorkshire pigs. Based on the QTL location, the PRKAG3 (protein kinase AMPactivated, γ3 subunit) or the RN (Rendement Napole) gene, as it is popularly known, was considered to be a good candidate for the observed effects. Differences in the PRKAG3 gene sequences of the founder animals of the intercross were analyzed. The RN- mutation previously reported was not present in the cross but three missense substitutions (changes affecting proteins) were identified. To test the hypothesis that at least one of these mutations was associated with differences in meat quality, more than 1,800 animals from several unrelated commercial lines were genotyped for the candidate gene differences and an association study was performed. The results provide strong support for the presence of new economically important alleles (gene forms) of the PRKAG3 gene affecting the glycogen content in the muscle and the resulting meat quality. Because of their prevalence in the more common commercial breeds, the potential implications for the pig industry and consumers are probably more important than the original discovery of the RN- mutation.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/swinereports_2001/5/
dc.identifier.articleid 1004
dc.identifier.contextkey 3234230
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath swinereports_2001/5
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/91307
dc.language.iso en
dc.relation.ispartofseries Animal Science Research Reports
dc.source.bitstream archive/lib.dr.iastate.edu/swinereports_2001/5/asl_1775.pdf|||Sat Jan 15 00:31:19 UTC 2022
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Sciences
dc.subject.keywords ASL R1775
dc.title New Alleles in the “RN gene” Associated with Low Glycogen Content in Pig Skeletal Muscle and Improved Meat Quality
dc.type article
dc.type.genre breeding_physiology
dspace.entity.type Publication
relation.isAuthorOfPublication a5915699-0c8a-411e-a601-1564d7090ab9
relation.isSeriesOfPublication 7f3839b7-b833-4418-a6fa-adda2b23950a
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