“Just right” combinations of adjuvants with nanoscale carriers activate aged dendritic cells without overt inflammation
Date
2023-03-09
Authors
Ananya, Ananya
Holden, Kaitlyn G.
Gu, Zhiling
Wannemuehler, Michael J.
Kohut, Marian L.
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BMC
Abstract
The loss in age-related immunological markers, known as immunosenescence, is caused by a combination of factors, one of which is inflammaging. Inflammaging is associated with the continuous basal generation of proinflammatory cytokines. Studies have demonstrated that inflammaging reduces the effectiveness of vaccines. Strategies aimed at modifying baseline inflammation are being developed to improve vaccination responses in older adults. Dendritic cells have attracted attention as an age-specific target because of their significance in immunization as antigen presenting cells that stimulate T lymphocytes.
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article
Comments
This article is published as Ananya, Ananya, Kaitlyn G. Holden, Zhiling Gu, Dan Nettleton, Surya K. Mallapragada, Michael J. Wannemuehler, Marian L. Kohut, and Balaji Narasimhan. “Just right” combinations of adjuvants with nanoscale carriers activate aged dendritic cells without overt inflammation. Immunity & Ageing 20, no. 1 (2023): 1-16.
DOI: 10.1186/s12979-023-00332-0.
Copyright 2023 The Author(s).
Attribution 4.0 International (CC BY 4.0).
Posted with permission.