Effects of yohimbine, an alpha 2-antagonistic reversal agent, on physiological recovery parameters of anesthetized sows

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dc.contributor.author Pairis-Garcia, Monique
dc.contributor.author Johnson, Anna
dc.contributor.author Millman, Suzanne
dc.contributor.author Stalder, Kenneth
dc.contributor.author Karriker, Locke
dc.contributor.department Animal Science
dc.contributor.department Veterinary Diagnostic and Production Animal Medicine
dc.date 2018-03-22T13:04:37.000
dc.date.accessioned 2020-06-29T23:40:35Z
dc.date.available 2020-06-29T23:40:35Z
dc.date.copyright Wed Jan 01 00:00:00 UTC 2014
dc.date.issued 2014-01-01
dc.description.abstract <p><strong>Objective:</strong> To evaluate the efficacy of yohimbine as an anesthetic reversal agent for sows anesthetized with a combination of xylazine, ketamine, and telazol.</p> <p><strong>Materials and methods: </strong>Anesthesia was induced with xylazine, ketamine, and telazol in a single syringe, injected intramuscularly (IM). Following a 20-minute stabilization period, palpebral reflex was evaluated, and if absent, sows were injected IM with sterile saline (Control sows; n = 12) or yohimbine HCl (0.1 mg per kg; Yohimbine sows; n = 12). Data collected included insensibility measures (palpebral reflex, jaw tone, nose prick, alertness to human approach test, body posture) and physiologic measurements (heart rate, rectal temperature, respiratory rate, oxyhemoglobin saturation). Data was collected every 10 minutes until complete sensibility was attained.</p> <p><strong>Results: </strong>Yohimbine sows recovered from anesthesia 162 minutes earlier than Control sows (<em>P</em> < .01). For all insensibility measures, Yohimbine sows regained a normal response more quickly than Control sows (<em>P</em> < .001). In addition, Yohimbine sows maintained greater heart rate (<em>P </em>< .05) and rectal temperature (<em>P</em> < .001) between onset of anesthesia (the time anesthetic agents were injected) to completion of the trial (when sow attained complete return to sensibility). Respiratory rate and oxyhemoglobin saturation were maintained within normal physiological ranges throughout anesthesia, confirming that respiratory capability was not compromised under this anesthetic protocol.</p> <p><strong>Implications: </strong>Yohimbine is an effective reversal agent in sows anesthetized with xylazine, ketamine, and telazol administered simultaneously. This agent can be used by veterinarians to ensure a quicker recovery from anesthesia with minimal complications.</p>
dc.description.comments <p>This article is from Pairis-Garcia, Monique D., Anna K. Johnson, Suzanne T. Millman, Kenneth J. Stalder, and Locke A. Karriker. "Effects of yohimbine, an alpha 2-antagonistic reversal agent, on physiological recovery parameters of anesthetized sows." Journal of Swine Health and Production 22, no. 1 (2014): 16-23. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/ans_pubs/406/
dc.identifier.articleid 1406
dc.identifier.contextkey 11811631
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ans_pubs/406
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/9831
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/ans_pubs/406/0-Stalder_Permission_from_AASV.pdf|||Sat Jan 15 00:08:33 UTC 2022
dc.source.uri https://www.aasv.org/shap/issues/v22n1/v22n1p16.pdf
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Sciences
dc.subject.disciplines Large or Food Animal and Equine Medicine
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.subject.keywords swine
dc.subject.keywords anesthesia
dc.subject.keywords yohimbine
dc.subject.keywords reversal agent
dc.title Effects of yohimbine, an alpha 2-antagonistic reversal agent, on physiological recovery parameters of anesthetized sows
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isOrgUnitOfPublication 85ecce08-311a-441b-9c4d-ee2a3569506f
relation.isOrgUnitOfPublication 5ab07352-4171-4f53-bbd7-ac5d616f7aa8
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