Characterizing Biomolecular Structure Features through an Innovative Elliptical Dichroism Spectrometry for Cancer Detection
Date
2024-09-24
Authors
Asad, Yusuf
Jangili, Keerthi Priya
Arshad, Amara
Elma, Maliha
Rasuleva, Komila
Akinlalu, Alfred
Gao, Tommy
Tida, Umamaheswara Rao
Sun, Dali
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Elsevier Ltd
Abstract
This research introduces a novel method for evaluating the structural features of biomolecules, utilizing our innovative Elliptical Dichroism (ED) spectrometer specifically designed for stereochemical analysis. By integrating ED spectrometry with autocorrelation (AC) analysis, we investigate the conformational characteristics of biological molecules such as amino acids, proteins, and extracellular vesicles (EVs) induced by elliptically polarized UV absorption. Our streamlined approach offers a cost-effective and portable solution with minimal sample consumption and supports multiple working modes to efficiently characterize biomolecular structures. The insight from this new approach demonstrates potential applications in using biomolecular characterization for cancer detection.
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article
Comments
This article is published as Asad, Yusuf, Keerthi Priya Jangili, Amara Arshad, Maliha Elma, Komila Rasuleva, Alfred Akinlalu, Tommy Gao, Umamaheswara Rao Tida, Wenjie Xia, and Dali Sun. "Characterizing Biomolecular Structure Features through an Innovative Elliptical Dichroism Spectrometry for Cancer Detection." Heliyon (2024).
doi: https://doi.org/10.1016/j.heliyon.2024.e38399.
Rights Statement
© 2024 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).