Suppression of Mannheimia (Pasteurella) haemolytica serovar 1 infection in lambs by intrapulmonary administration of ovine antimicrobial anionic peptide

dc.contributor.author Kalfa, V.
dc.contributor.author Palmquist, D.
dc.contributor.author Ackermann, Mark
dc.contributor.author Ackermann, Mark
dc.contributor.author Brogden, Kim
dc.contributor.department Veterinary Pathology
dc.date 2018-02-13T06:26:39.000
dc.date.accessioned 2020-07-07T05:15:54Z
dc.date.available 2020-07-07T05:15:54Z
dc.date.embargo 2013-02-26
dc.date.issued 2001-06-01
dc.description.abstract <p>In this study, the efficacy of ovine antimicrobial anionic peptide (AP) was assessed in a lamb model of acute pneumonia. A single intratracheal dose of the peptide, H-DDDDDDD-OH (0.5 mg) reduced pulmonary inflammation and the concentration of <em>Mannheimia</em> (<em>Pasteurella) haemolytica</em> in infected lung tissue. Administration of H-DDDDDDD-OH after infection was more effective in reducing the consolidation and lesion scores at the deposition site than its administration prior to infection. Hence, the in vivo effectiveness of AP suggests that it may have applications in the treatment of pulmonary infections. Further studies are needed to confirm these findings and also to determine the optimal doses and intervals of H-DDDDDDD-OH therapy.</p>
dc.description.comments <p>This article is from <em>International Journal of Antimicrobial Agents </em>17, no. 5 (June 2001): 505–510, doi:<a href="http://dx.doi.org/10.1016/S0924-8579(01)00319-3" id="x-ddDoi" target="_blank">10.1016/S0924-8579(01)00319-3</a>.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vpath_pubs/41/
dc.identifier.articleid 1041
dc.identifier.contextkey 3792001
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vpath_pubs/41
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92466
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vpath_pubs/41/2001_Kalfa_SuppressionMannheimiaPasteurella.pdf|||Sat Jan 15 00:09:10 UTC 2022
dc.source.uri 10.1016/S0924-8579(01)00319-3
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.subject.keywords Anionic peptides
dc.subject.keywords Antimicrobial peptides
dc.subject.keywords Respiratory infections
dc.subject.keywords Mannheimia (Pasteurella) haemolytica
dc.title Suppression of Mannheimia (Pasteurella) haemolytica serovar 1 infection in lambs by intrapulmonary administration of ovine antimicrobial anionic peptide
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 86c1ed73-b60d-48ce-8f35-449bc320a693
relation.isOrgUnitOfPublication cf38d7e3-b5f8-4859-83e3-ae8fab6a4c5f
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