Determination of 1-methyl-1H-1,2,4-triazole in soils contaminated by rocket fuel using solid-phase microextraction, isotope dilution and gas chromatography–mass spectrometry

dc.contributor.author Yegemova, Saltanat
dc.contributor.author Bakaikina, Nadezhda
dc.contributor.author Kenessov, Bulat
dc.contributor.author Koziel, Jacek
dc.contributor.author Koziel, Jacek
dc.contributor.author Nauryzbayev, Mikhail
dc.contributor.department Food Science and Human Nutrition
dc.contributor.department Civil, Construction and Environmental Engineering
dc.contributor.department Agricultural and Biosystems Engineering
dc.contributor.department Toxicology
dc.date 2019-01-02T02:25:41.000
dc.date.accessioned 2020-06-29T22:43:36Z
dc.date.available 2020-06-29T22:43:36Z
dc.date.copyright Thu Jan 01 00:00:00 UTC 2015
dc.date.issued 2015-10-01
dc.description.abstract <p>Environmental monitoring of Central Kazakhstan territories where heavy space booster rockets land requires fast, efficient, and inexpensive analytical methods. The goal of this study was to develop a method for quantitation of the most stable transformation product of rocket fuel, i.e., highly toxic unsymmetrical dimethylhydrazine – 1-methyl-1H-1,2,4-triazole (MTA) in soils using solid-phase microextraction (SPME) in combination with gas chromatography–mass spectrometry. Quantitation of organic compounds in soil samples by SPME is complicated by a matrix effect. Thus, an isotope dilution method was chosen using deuterated analyte (1-(trideuteromethyl)-1H-1,2,4-triazole; MTA-d3) for matrix effect control. The work included study of the matrix effect, optimization of a sample equilibration stage (time and temperature) after spiking MTA-d3 and validation of the developed method. Soils of different type and water content showed an order of magnitude difference in SPME effectiveness of the analyte. Isotope dilution minimized matrix effects. However, proper equilibration of MTA-d3 in soil was required. Complete MTA-d3 equilibration at temperatures below 40 °C was not observed. Increase of temperature to 60 °C and 80 °C enhanced equilibration reaching theoretical MTA/MTA-d3 response ratios after 13 and 3 h, respectively. Recoveries of MTA depended on concentrations of spiked MTA-d3 during method validation. Lowest spiked MTA-d3 concentration (0.24 mg kg−1) provided best MTA recoveries (91–121%). Addition of excess water to soil sample prior to SPME increased equilibration rate, but it also decreased method sensitivity. Method detection limit depended on soil type, water content, and was always below 1 mg kg−1. The newly developed method is fully automated, and requires much lower time, labor and financial resources compared to known methods.</p>
dc.description.comments <p>This is a manuscript of an article published as Yegemova, Saltanat, Nadezhda V. Bakaikina, Bulat Kenessov, Jacek A. Koziel, and Mikhail Nauryzbayev. "Determination of 1-methyl-1H-1, 2, 4-triazole in soils contaminated by rocket fuel using solid-phase microextraction, isotope dilution and gas chromatography–mass spectrometry." <em>Talanta</em> 143 (2015): 226-233. DOI: <a href="http://dx.doi.org/10.1016/j.talanta.2015.05.045" target="_blank">10.1016/j.talanta.2015.05.045</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/abe_eng_pubs/908/
dc.identifier.articleid 2199
dc.identifier.contextkey 11950243
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath abe_eng_pubs/908
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/1722
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/abe_eng_pubs/908/2015_Koziel_Determination1Methyl.pdf|||Sat Jan 15 02:27:51 UTC 2022
dc.source.uri 10.1016/j.talanta.2015.05.045
dc.subject.disciplines Agriculture
dc.subject.disciplines Bioresource and Agricultural Engineering
dc.subject.disciplines Environmental Monitoring
dc.subject.disciplines Organic Chemistry
dc.subject.keywords Solid-phase microextraction
dc.subject.keywords 1-methyl-1H-1
dc.subject.keywords 2
dc.subject.keywords 4-triazole
dc.subject.keywords Soil
dc.subject.keywords Soil equilibrationInternal standard
dc.subject.keywords Matrix effect
dc.title Determination of 1-methyl-1H-1,2,4-triazole in soils contaminated by rocket fuel using solid-phase microextraction, isotope dilution and gas chromatography–mass spectrometry
dc.type article
dc.type.genre article
dspace.entity.type Publication
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