Microfluidic Organ‐on‐a‐Chip Technology for Advancement of Drug Development and Toxicology

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2015-07-15
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Caplin, Jeremy
Granados, Norma
James, Myra
Montazami, Reza
Hashemi, Nicole
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Mechanical EngineeringCenter for Advanced Host Defenses, Immunobiotics and Translational Comparative Medicine
Abstract

In recent years, the exploitation of phenomena surrounding microfluidics has seen an increase in popularity, as researchers have found a way to use their unique properties to create superior design alternatives. One such application is representing the properties and functions of different organs on a microscale chip for the purpose of drug testing or tissue engineering. With the introduction of “organ‐on‐a‐chip” systems, researchers have proposed various methods on various organ‐on‐a‐chip systems to mimic their in vivo counterparts. In this article, a systematic approach is taken to review current technologies pertaining to organ‐on‐a‐chip systems. Design processes with attention to the particular instruments, cells, and materials used are presented.

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This is the peer-reviewed version of the following article: Caplin, Jeremy D., Norma G. Granados, Myra R. James, Reza Montazami, and Nastaran Hashemi. "Microfluidic organ‐on‐a‐chip technology for advancement of drug development and toxicology." Advanced Healthcare Materials 4, no. 10 (2015): 1426-1450, which has been published in final form at DOI: 10.1002/adhm.201500040. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Posted with permission.

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Thu Jan 01 00:00:00 UTC 2015
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