Background—Dementia and mild cognitive impairment (MCI) are under-recognized in community settings. This may be due in part to the lack of brief dementia screening tools available to clinicians. We compared two brief, informant-based screening tests: the AD8 and the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) in a community-based neurology practice in the Midwestern United States Methods—We examined 186 consecutive patients (44 controls, 13 with MCI, and 129 with dementia). Receiver operator characteristic curves were used to examine the ability of AD8 and IQCODE to discriminate between controls and MCI or dementia. Sensitivity, specificity, predictive values, and likelihood ratios were reported. Results—AD8 differentiated healthy controls from MCI (p