Effects of nano-confinement and conformational mobility on molecular imprinting of cross-linked micelles

Thumbnail Image
Date
2019-01-01
Authors
Chen, Kaiqian
Zhao, Yan
Major Professor
Advisor
Committee Member
Journal Title
Journal ISSN
Volume Title
Publisher
Authors
Person
Research Projects
Organizational Units
Organizational Unit
Journal Issue
Is Version Of
Versions
Series
Department
Chemistry
Abstract

Molecular imprinting is a facile method to create guest-complementary binding sites in a cross-linked polymeric network. When performed within cross-linked micelles, the resulting molecularly imprinted nanoparticles (MINPs) exhibited an extraordinary ability to distinguish subtle structural changes in the guest, including the shift of a hydrophilic or hydrophobic group by 1 carbon and addition of a single methylene/methyl group. A high surface-cross-linking density prior to core-cross-linking was key to the high-fidelity imprinting, enhancing both the binding affinity of the imprinted micelle for the template and selectivity among structural analogues. Whereas the imprinted site closely complemented the hydrophilic surface anchoring group and rigid hydrophobic aromatic core, it was expanded significantly for a conformationally mobile small group (i.e., methoxy).

Comments

This article is published as Chen, Kaiqian, and Yan Zhao. "Effects of nano-confinement and conformational mobility on molecular imprinting of cross-linked micelles." Organic & Biomolecular Chemistry 17, no. 37 (2019): 8611-8617. DOI: 10.1039/C9OB01440C. Posted with permission.

Description
Keywords
Citation
DOI
Copyright
Tue Jan 01 00:00:00 UTC 2019
Collections