Effects of nano-confinement and conformational mobility on molecular imprinting of cross-linked micelles

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dc.contributor.author Chen, Kaiqian
dc.contributor.author Zhao, Yan
dc.contributor.author Zhao, Yan
dc.contributor.department Chemistry
dc.date 2020-01-04T09:06:48.000
dc.date.accessioned 2020-06-30T01:17:21Z
dc.date.available 2020-06-30T01:17:21Z
dc.date.copyright Tue Jan 01 00:00:00 UTC 2019
dc.date.issued 2019-01-01
dc.description.abstract <p>Molecular imprinting is a facile method to create guest-complementary binding sites in a cross-linked polymeric network. When performed within cross-linked micelles, the resulting molecularly imprinted nanoparticles (MINPs) exhibited an extraordinary ability to distinguish subtle structural changes in the guest, including the shift of a hydrophilic or hydrophobic group by 1 carbon and addition of a single methylene/methyl group. A high surface-cross-linking density prior to core-cross-linking was key to the high-fidelity imprinting, enhancing both the binding affinity of the imprinted micelle for the template and selectivity among structural analogues. Whereas the imprinted site closely complemented the hydrophilic surface anchoring group and rigid hydrophobic aromatic core, it was expanded significantly for a conformationally mobile small group (i.e., methoxy).</p>
dc.description.comments <p>This article is published as Chen, Kaiqian, and Yan Zhao. "Effects of nano-confinement and conformational mobility on molecular imprinting of cross-linked micelles." <em>Organic & Biomolecular Chemistry</em> 17, no. 37 (2019): 8611-8617. DOI: <a href="http://dx.doi.org/10.1039/C9OB01440C" target="_blank">10.1039/C9OB01440C</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/chem_pubs/1195/
dc.identifier.articleid 2200
dc.identifier.contextkey 16108224
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath chem_pubs/1195
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/14504
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/chem_pubs/1195/2019_ZhaoYan_EffectsNanoconfinement.pdf|||Fri Jan 14 19:02:07 UTC 2022
dc.source.uri 10.1039/C9OB01440C
dc.subject.disciplines Nanoscience and Nanotechnology
dc.subject.disciplines Organic Chemistry
dc.title Effects of nano-confinement and conformational mobility on molecular imprinting of cross-linked micelles
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 82f430d1-77c0-43c2-8bd5-52f3787cc4ba
relation.isOrgUnitOfPublication 42864f6e-7a3d-4be3-8b5a-0ae3c3830a11
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