Ecology of Porcine Astrovirus Type 3 in a Herd with Associated Neurologic Disease

Date
2020-09-07
Authors
Rawal, Gaurav
Matias Ferreyra, Franco
Macedo, Nubia
Bradner, Laura
Harmon, Karen
Allison, Grant
Linhares, Daniel
Wilberts, Bailey
Journal Title
Journal ISSN
Volume Title
Publisher
Altmetrics
Authors
Research Projects
Organizational Units
Journal Issue
Series
Abstract

Astroviruses (AstVs) cause disease in a wide variety of species. Porcine AstVs are highly genetically diverse and conventionally assigned to five genetic lineages (PoAstV1-5). Due to the increasing evidence that porcine astrovirus type 3 (PoAstV3) is a cause of encephalomyelitis in swine and to elucidate important ecologic characteristics, the infection dynamics and environmental distribution of PoAstV3 were investigated in a herd with PoAstV3-associated neurologic disease. Over a 22 week period, the frequency of PoAstV3 fecal shedding varied by pig and age. The peak detection by RT-qPCR of PoAstV3 on fecal swabs (95%; 61 of 64) occurred at 3 weeks of age. The lowest frequency of detection was at 21 weeks of age (4%; 2 of 47); however, the frequency increased to 41% (19 of 46) at the final sampling time point (25 weeks of age). Viremia was rare (0.9%: 4 of 433). Detection in oral fluid was consistent with 75% to 100% of samples positive at each time point. Pens and feeders also had a high rate of detection with a majority of samples positive at a majority of sampling time points. Based on the data presented, PoAstV3 can be consistently detected in the environment with a majority of pigs being infected and a subset intermittently shedding the virus in feces out to 25 weeks of age. These findings suggest the importance of as-yet unidentified risk factors associated with the development of PoAstV3-associated polioencephalomyelitis.

Description

This article is published as Rawal, Gaurav, Franco Matias Ferreyra, Nubia R. Macedo, Laura K. Bradner, Karen M. Harmon, Grant Allison, Daniel CL Linhares, and Bailey L. Arruda. "Ecology of Porcine Astrovirus Type 3 in a Herd with Associated Neurologic Disease." Viruses 12, no. 9 (2020): 992. DOI: 10.3390/v12090992. Posted with permission.

Keywords
astrovirus, porcine astrovirus type 3, neurologic disease, longitudinal study, swine
Citation
DOI
Collections