Ecology of Porcine Astrovirus Type 3 in a Herd with Associated Neurologic Disease Rawal, Gaurav Linhares, Daniel Macedo, Nubia Bradner, Laura Harmon, Karen Allison, Grant Linhares, Daniel Wilberts, Bailey
dc.contributor.department Veterinary Diagnostic and Production Animal Medicine
dc.contributor.department Veterinary Diagnostic Laboratory 2020-09-14T22:34:44.000 2021-02-26T13:41:00Z 2021-02-26T13:41:00Z Wed Jan 01 00:00:00 UTC 2020 2020-09-07
dc.description.abstract <p>Astroviruses (AstVs) cause disease in a wide variety of species. Porcine AstVs are highly genetically diverse and conventionally assigned to five genetic lineages (PoAstV1-5). Due to the increasing evidence that porcine astrovirus type 3 (PoAstV3) is a cause of encephalomyelitis in swine and to elucidate important ecologic characteristics, the infection dynamics and environmental distribution of PoAstV3 were investigated in a herd with PoAstV3-associated neurologic disease. Over a 22 week period, the frequency of PoAstV3 fecal shedding varied by pig and age. The peak detection by RT-qPCR of PoAstV3 on fecal swabs (95%; 61 of 64) occurred at 3 weeks of age. The lowest frequency of detection was at 21 weeks of age (4%; 2 of 47); however, the frequency increased to 41% (19 of 46) at the final sampling time point (25 weeks of age). Viremia was rare (0.9%: 4 of 433). Detection in oral fluid was consistent with 75% to 100% of samples positive at each time point. Pens and feeders also had a high rate of detection with a majority of samples positive at a majority of sampling time points. Based on the data presented, PoAstV3 can be consistently detected in the environment with a majority of pigs being infected and a subset intermittently shedding the virus in feces out to 25 weeks of age. These findings suggest the importance of as-yet unidentified risk factors associated with the development of PoAstV3-associated polioencephalomyelitis.</p>
dc.description.comments <p>This article is published as Rawal, Gaurav, Franco Matias Ferreyra, Nubia R. Macedo, Laura K. Bradner, Karen M. Harmon, Grant Allison, Daniel CL Linhares, and Bailey L. Arruda. "Ecology of Porcine Astrovirus Type 3 in a Herd with Associated Neurologic Disease." <em>Viruses</em> 12, no. 9 (2020): 992. DOI: <a href="" target="_blank">10.3390/v12090992</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/
dc.identifier.articleid 1202
dc.identifier.contextkey 19398326
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vdpam_pubs/198
dc.language.iso en
dc.source.bitstream archive/|||Fri Jan 14 22:00:09 UTC 2022
dc.source.uri 10.3390/v12090992
dc.subject.disciplines Large or Food Animal and Equine Medicine
dc.subject.disciplines Veterinary Infectious Diseases
dc.subject.keywords astrovirus
dc.subject.keywords porcine astrovirus type 3
dc.subject.keywords neurologic disease
dc.subject.keywords longitudinal study
dc.subject.keywords swine
dc.title Ecology of Porcine Astrovirus Type 3 in a Herd with Associated Neurologic Disease
dc.type article
dc.type.genre article
dspace.entity.type Publication
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relation.isAuthorOfPublication 3ce0db9e-1f42-4d29-b389-2364b3470254
relation.isOrgUnitOfPublication 5ab07352-4171-4f53-bbd7-ac5d616f7aa8
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