Fluorinated Analogs of Malachite Green: Synthesis and Toxicity

Date
2008-04-27
Authors
Kraus, George
Kraus, George
Jeon, Insik
Nilsen-Hamilton, Marit
Awad, Ahmed
Nilsen-Hamilton, Marit
Banerjee, Jayeeta
Parvin, Bahram
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Altmetrics
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Chemistry
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Biochemistry, Biophysics and Molecular BiologyChemistry
Abstract

A series of fluorinated analogs of malachite green (MG) have been synthesizedand their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell lineexamined. The toxicity profiles were found to be different for these two species. Twoanalogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem tobe the most promising analogs because they showed the lowest toxicity to the human cells.

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Reprinted (adapted) with permission from Molecules, 2008; 13(4); 986-994. Doi: 10.3390/molecules13040986. Posted with permission.

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