Fluorinated Analogs of Malachite Green: Synthesis and Toxicity

Date
2008-04-27
Authors
Kraus, George
Kraus, George
Jeon, Insik
Nilsen-Hamilton, Marit
Awad, Ahmed
Nilsen-Hamilton, Marit
Banerjee, Jayeeta
Parvin, Bahram
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Abstract

A series of fluorinated analogs of malachite green (MG) have been synthesizedand their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell lineexamined. The toxicity profiles were found to be different for these two species. Twoanalogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem tobe the most promising analogs because they showed the lowest toxicity to the human cells.

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<p>Reprinted (adapted) with permission from <em>Molecules,</em> 2008; 13(4); 986-994. Doi: <a href="http://dx.doi.org/10.3390/molecules13040986" target="_blank">10.3390/molecules13040986</a>. Posted with permission.</p>
Keywords
Malachite Green, Malachite Green analogs, Bathochromic shift, Toxicity, Saccharomyces cerevisiae, human ovarian epithelial cells.
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