Fluorinated Analogs of Malachite Green: Synthesis and Toxicity
Is Version Of
A series of fluorinated analogs of malachite green (MG) have been synthesizedand their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell lineexamined. The toxicity profiles were found to be different for these two species. Twoanalogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem tobe the most promising analogs because they showed the lowest toxicity to the human cells.
Reprinted (adapted) with permission from Molecules, 2008; 13(4); 986-994. Doi: 10.3390/molecules13040986. Posted with permission.