Fluorinated Analogs of Malachite Green: Synthesis and Toxicity
Fluorinated Analogs of Malachite Green: Synthesis and Toxicity
Date
2008-04-27
Authors
Kraus, George
Kraus, George
Jeon, Insik
Nilsen-Hamilton, Marit
Awad, Ahmed
Nilsen-Hamilton, Marit
Banerjee, Jayeeta
Parvin, Bahram
Kraus, George
Jeon, Insik
Nilsen-Hamilton, Marit
Awad, Ahmed
Nilsen-Hamilton, Marit
Banerjee, Jayeeta
Parvin, Bahram
Major Professor
Advisor
Committee Member
Journal Title
Journal ISSN
Volume Title
Publisher
Altmetrics
Authors
Research Projects
Organizational Units
Journal Issue
Series
Department
Biochemistry, Biophysics and Molecular BiologyChemistry
Abstract
A series of fluorinated analogs of malachite green (MG) have been synthesizedand their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell lineexamined. The toxicity profiles were found to be different for these two species. Twoanalogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem tobe the most promising analogs because they showed the lowest toxicity to the human cells.
Comments
Reprinted (adapted) with permission from Molecules, 2008; 13(4); 986-994. Doi: 10.3390/molecules13040986. Posted with permission.