Fluorinated Analogs of Malachite Green: Synthesis and Toxicity

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dc.contributor.author Kraus, George
dc.contributor.author Jeon, Insik
dc.contributor.author Nilsen-Hamilton, Marit
dc.contributor.author Awad, Ahmed
dc.contributor.author Nilsen-Hamilton, Marit
dc.contributor.author Parvin, Bahram
dc.contributor.department Biochemistry, Biophysics and Molecular Biology
dc.contributor.department Chemistry
dc.date 2018-02-17T07:59:16.000
dc.date.accessioned 2020-06-30T01:19:36Z
dc.date.available 2020-06-30T01:19:36Z
dc.date.copyright Tue Jan 01 00:00:00 UTC 2008
dc.date.issued 2008-04-27
dc.description.abstract <p>A series of fluorinated analogs of malachite green (MG) have been synthesizedand their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell lineexamined. The toxicity profiles were found to be different for these two species. Twoanalogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem tobe the most promising analogs because they showed the lowest toxicity to the human cells.</p>
dc.description.comments <p>Reprinted (adapted) with permission from <em>Molecules,</em> 2008; 13(4); 986-994. Doi: <a href="http://dx.doi.org/10.3390/molecules13040986" target="_blank">10.3390/molecules13040986</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/chem_pubs/363/
dc.identifier.articleid 1379
dc.identifier.contextkey 7925872
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath chem_pubs/363
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/14814
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/chem_pubs/363/2008_KrausGA_FluorinatedAnalogsMalachite.pdf|||Fri Jan 14 23:47:46 UTC 2022
dc.source.uri 10.3390/molecules13040986
dc.subject.disciplines Chemistry
dc.subject.disciplines Organic Chemistry
dc.subject.disciplines Other Chemistry
dc.subject.disciplines Polymer Chemistry
dc.subject.keywords Malachite Green
dc.subject.keywords Malachite Green analogs
dc.subject.keywords Bathochromic shift
dc.subject.keywords Toxicity
dc.subject.keywords Saccharomyces cerevisiae
dc.subject.keywords human ovarian epithelial cells.
dc.title Fluorinated Analogs of Malachite Green: Synthesis and Toxicity
dc.type article
dc.type.genre article
dspace.entity.type Publication
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