Field practitioners are frequently confronted with the problem of diagnosis of disease of pregnant ewes that show weakness, depression, anorexia and a variety of central nervous disturbances as incoordination, circling, convulsions or coma. The frequent diagnosis of pregnancy disease in these cases may be misleading as to the prevalence of this condition. This syndrome may be confused with listeriosis, brain abscesses, enterotoxemia, hemorrhagic septicemia, plant and chemical poisons and rickettsial conjunctivitis.