G-Wires: Self-Assembly of a Telomeric Oligonucleotide, d(GGGGTTGGGG), into Large Superstructures

dc.contributor.author Marsh, Thomas
dc.contributor.author Henderson, Eric
dc.contributor.author Henderson, Eric
dc.contributor.department Zoology and Genetics
dc.date 2018-02-18T09:55:25.000
dc.date.accessioned 2020-07-07T05:16:51Z
dc.date.available 2020-07-07T05:16:51Z
dc.date.copyright Sat Jan 01 00:00:00 UTC 1994
dc.date.issued 1994-09-01
dc.description.abstract <p>The telomeric DNA oligonucleotide 5’-G4T~G4-3’ (Tet 1.5) spontaneously assembles into large superstructures we have termed G-wires. G-wires can be resolved by gel electrophoresis as a ladder pattern. The self-association of Tet 1.5 is noncovalent and exhibits characteristics of G4-DNA, a parallel fourstranded structure stabilized by guanine tetrads. Formation of G-wires is dependent upon the presence of Na+ and/or K+, and once formed, G-wires are resistant to denaturation. The results described here extend our understanding of the structural potential of G-rich nucleic acids and may provide insight into the possible roles of G-rich sequences and the novel structures they can form in biological systems.</p>
dc.description.comments <p>Reprinted (adapted) with permission from G-Wires: Self-Assembly of a Telomeric Oligonucleotide, d(GGGGTTGGGG), into Large Superstructures. Thomas C. Marsh and Eric Henderson Biochemistry <strong>1994</strong> <em>33</em> (35), 10718-10724. DOI: 10.1021/bi00201a020. Copyright 1994 American Chemical Society.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/zool_pubs/25/
dc.identifier.articleid 1029
dc.identifier.contextkey 10133725
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath zool_pubs/25
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92634
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/zool_pubs/25/0-Permission_for_ACS_1994_G_Wires.pdf|||Fri Jan 14 22:56:28 UTC 2022
dc.source.bitstream archive/lib.dr.iastate.edu/zool_pubs/25/1994_Henderson_GWires.pdf|||Fri Jan 14 22:56:29 UTC 2022
dc.source.uri 10.1021/bi00201a020
dc.subject.disciplines Cell and Developmental Biology
dc.subject.disciplines Genetics and Genomics
dc.subject.disciplines Zoology
dc.title G-Wires: Self-Assembly of a Telomeric Oligonucleotide, d(GGGGTTGGGG), into Large Superstructures
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 68bc511a-afd6-4353-ae20-066de33682b9
relation.isOrgUnitOfPublication 4a2929da-5374-4338-b62f-f5fd9e156ef9
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