Concurrent renal amyloidosis and thymoma resulting in a fatal ventricular thrombus in a dog

dc.contributor.author Smith, Jodi
dc.contributor.author Loewen, Jennifer
dc.contributor.author Cianciolo, Rachel
dc.contributor.author Zhang, Liwen
dc.contributor.author Yaeger, Michael
dc.contributor.author Ward, Jessica
dc.contributor.author Ward, Jessica
dc.contributor.author Smith, Jodi
dc.contributor.author LeVine, Dana
dc.contributor.department Veterinary Pathology
dc.contributor.department Veterinary Clinical Sciences
dc.date 2018-06-15T03:27:53.000
dc.date.accessioned 2020-07-07T05:12:17Z
dc.date.available 2020-07-07T05:12:17Z
dc.date.copyright Mon Jan 01 00:00:00 UTC 2018
dc.date.issued 2018-01-01
dc.description.abstract <p>Thymoma‐associated nephropathies have been reported in people but not in dogs. In this report, we describe a dog with thymoma and concurrent renal amyloidosis. A 7‐year‐old castrated male Weimaraner was presented for progressive anorexia, lethargy, and tachypnea. The dog was diagnosed with azotemia, marked proteinuria, and a thymoma that was surgically removed. Postoperatively, the dog developed a large left ventricular thrombus and was euthanized. Necropsy confirmed the presence of a left ventricular thrombus and histopathology revealed renal amyloidosis. We speculate that the renal amyloidosis occurred secondary to the thymoma, with amyloidosis in turn leading to nephrotic syndrome, hypercoagulability, and ventricular thrombosis. This case illustrates the potential for thymoma‐associated nephropathies to occur in dogs and that dogs suspected to have thymoma should have a urinalysis and urine protein creatinine ratio performed as part of the pre‐surgical database.</p>
dc.description.comments <p>This article is published as Loewen, Jennifer M., Rachel E. Cianciolo, Liwen Zhang, Michael Yaeger, Jessica L. Ward, Jodi D. Smith, and Dana N. LeVine. "Concurrent renal amyloidosis and thymoma resulting in a fatal ventricular thrombus in a dog." <em>Journal of veterinary internal medicine</em> (2018). doi: <a href="https://doi.org/10.1111/jvim.15062">10.1111/jvim.15062</a>.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vcs_pubs/17/
dc.identifier.articleid 1016
dc.identifier.contextkey 12318104
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vcs_pubs/17
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/91894
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vcs_pubs/17/2018_Ward_ConcurrentRenal.pdf|||Fri Jan 14 21:12:34 UTC 2022
dc.source.uri 10.1111/jvim.15062
dc.subject.disciplines Small or Companion Animal Medicine
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.title Concurrent renal amyloidosis and thymoma resulting in a fatal ventricular thrombus in a dog
dc.type article
dc.type.genre article
dspace.entity.type Publication
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