Concurrent renal amyloidosis and thymoma resulting in a fatal ventricular thrombus in a dog Smith, Jodi Loewen, Jennifer Cianciolo, Rachel Zhang, Liwen Yaeger, Michael Ward, Jessica Ward, Jessica Smith, Jodi LeVine, Dana
dc.contributor.department Veterinary Pathology
dc.contributor.department Veterinary Clinical Sciences 2018-06-15T03:27:53.000 2020-07-07T05:12:17Z 2020-07-07T05:12:17Z Mon Jan 01 00:00:00 UTC 2018 2018-01-01
dc.description.abstract <p>Thymoma‐associated nephropathies have been reported in people but not in dogs. In this report, we describe a dog with thymoma and concurrent renal amyloidosis. A 7‐year‐old castrated male Weimaraner was presented for progressive anorexia, lethargy, and tachypnea. The dog was diagnosed with azotemia, marked proteinuria, and a thymoma that was surgically removed. Postoperatively, the dog developed a large left ventricular thrombus and was euthanized. Necropsy confirmed the presence of a left ventricular thrombus and histopathology revealed renal amyloidosis. We speculate that the renal amyloidosis occurred secondary to the thymoma, with amyloidosis in turn leading to nephrotic syndrome, hypercoagulability, and ventricular thrombosis. This case illustrates the potential for thymoma‐associated nephropathies to occur in dogs and that dogs suspected to have thymoma should have a urinalysis and urine protein creatinine ratio performed as part of the pre‐surgical database.</p>
dc.description.comments <p>This article is published as Loewen, Jennifer M., Rachel E. Cianciolo, Liwen Zhang, Michael Yaeger, Jessica L. Ward, Jodi D. Smith, and Dana N. LeVine. "Concurrent renal amyloidosis and thymoma resulting in a fatal ventricular thrombus in a dog." <em>Journal of veterinary internal medicine</em> (2018). doi: <a href="">10.1111/jvim.15062</a>.</p>
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dc.identifier.articleid 1016
dc.identifier.contextkey 12318104
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dc.language.iso en
dc.source.bitstream archive/|||Fri Jan 14 21:12:34 UTC 2022
dc.source.uri 10.1111/jvim.15062
dc.subject.disciplines Small or Companion Animal Medicine
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.title Concurrent renal amyloidosis and thymoma resulting in a fatal ventricular thrombus in a dog
dc.type article
dc.type.genre article
dspace.entity.type Publication
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