Several small surveys and one large survey were conducted in Texas in order to determine the prevalence of Clostridium difficile (Cd) in food producing animals and retail meats. Composite fecal samples (n = 1008) from various age groups of commercial swine and pork trim (n = 62) from a sausage processing plant were collected in 2006 from an integrated swine operation. Samples were collected from commercial poultry and consisted of feces from 70-week-old laying hens (n = 50) and cecal contents from 28-day-old broiler chickens (n = 36). Cattle fecal samples were collected weekly from 14, !-year-old dairy calves (n = 64).