Genomic Insights into Campylobacter jejuni Virulence and Population Genetics

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2016-01-01
Authors
Wu, Zuowei
Zhang, Qijing
Mou, Kathy
Sahin, Orhan
Zhang, Qijing
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Veterinary Microbiology and Preventive MedicineVeterinary Diagnostic and Production Animal Medicine
Abstract

Campylobacter jejuni has long been recognized as a main food-borne pathogen in many parts of the world. Natural reservoirs include a wide variety of domestic and wild birds and mammals, whose intestines offer a suitable biological niche for the survival and dissemination of the organism. Understanding the genetic basis of the biology and pathogenicity of C. jejuni is vital to prevent and control Campylobacter-associated infections. The recent progress in sequencing techniques has allowed for a rapid increase in our knowledge of the molecular biology and the genetic structures of Campylobacter. Single-molecule realtime (SMRT) sequencing, which goes beyond four-base sequencing, revealed the role of DNA methylation in modulating the biology and virulence of C. jejuni at the level of epigenetics. In this review, we will provide an up-to-date review on recent advances in understanding C. jejuni genomics, including structural features of genomes, genetic traits of virulence, population genetics, and epigenetics.

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This article is published as Wu, Zuowei, Kathy Mou, Orhan Sahin, and Qijing Zhang. "Genomic Insights into Campylobacter jejuni Virulence and Population Genetics." Infectious Diseases and Translational Medicine 2, no. 3 (2016): 109-119. doi: 10.11979/idtm.201603005. Posted with permission.

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