Methods for assessing cell-mediated immunity in infectious disease resistance and in the development of vaccines

Thumbnail Image
Date
1995-04-15
Authors
Coe Clough, Nancy
Major Professor
Advisor
Committee Member
Journal Title
Journal ISSN
Volume Title
Publisher
Authors
Person
Research Projects
Organizational Units
Organizational Unit
Veterinary Microbiology and Preventive Medicine
Our faculty promote the understanding of causes of infectious disease in animals and the mechanisms by which diseases develop at the organismal, cellular and molecular levels. Veterinary microbiology also includes research on the interaction of pathogenic and symbiotic microbes with their hosts and the host response to infection.
Journal Issue
Is Version Of
Versions
Series
Abstract

Immunologic evaluation of vaccines has depended largely on the measurement of an antibody response in the serum of recipient animals. This approach, which worked well for diseases prevented in large part by humoral immunity, ignored the contributions cell-mediated immunity (CMI) or mucosal immunity make to providing protection against many infectious diseases. As a result of this approach, certain vaccines were marketed that produced a satisfactory antibody response but failed to protect vaccinates in the field from disease. In the modem biologics industry, there is increasing pressure for vaccine improvements and new technologic advancements to be based on a sound understanding of the entire basis for immunity, including cell-mediated, mucosal, and humoral immunity that develops after exposure to infectious disease agents.

Comments

This article is published as Coe-Clough, N.E. and J.A. Roth. 1995. Methods for assessing cell-mediated immunity in infectious disease resistance and in the development of vaccines. J Am Vet Med Assoc, 206:1208-1216.

Description
Keywords
Citation
DOI
Source
Copyright
Collections