Absence of glyphosate-induced effects on ovarian folliculogenesis and steroidogenesis

Thumbnail Image
Date
2020-06-24
Authors
Ganesan, Shanthi
McGuire, Bailey
Major Professor
Advisor
Committee Member
Journal Title
Journal ISSN
Volume Title
Publisher
Authors
Person
Keating, Aileen
Professor
Research Projects
Organizational Units
Organizational Unit
Animal Science

The Department of Animal Science originally concerned itself with teaching the selection, breeding, feeding and care of livestock. Today it continues this study of the symbiotic relationship between animals and humans, with practical focuses on agribusiness, science, and animal management.

History
The Department of Animal Husbandry was established in 1898. The name of the department was changed to the Department of Animal Science in 1962. The Department of Poultry Science was merged into the department in 1971.

Historical Names

Journal Issue
Is Version Of
Versions
Series
Department
Abstract

Glyphosate (GLY) is an herbicidal active ingredient and both in vitro and in vivo studies suggest that GLY alters ovarian function. To determine if a chronic GLY exposure model affected steroidogenesis or folliculogenesis in vivo, postnatal day 42 C57BL6 female mice were orally delivered vehicle control (saline) or GLY (2 mg/Kg) from a pipette tip five days per week for either five or ten weeks. Mice were euthanized at the pro-estrus stage of the estrous cycle. GLY exposure did not impact body weight gain, organ weights, or healthy follicle numbers. In addition, GLY exposure did not affect abundance of ovarian mRNA encoding kit ligand (Kitlg), KIT protooncogene receptor tyrosine kinase (c-Kit), insulin receptor (Insr), insulin receptor substrate (Irs1 or Irs2) and protein thymoma viral proto-oncogene 1 (AKT) or phosphorylated AKT. Ovarian mRNA or protein abundance of Star, 3β-hydroxysteroid dehydrogenase (Hsd3b1), Cyp11a1 or Cyp19a were also not altered by GLY. Circulating 17β-estradiol and progesterone concentration were unaffected by GLY exposure. In conclusion, chronic GLY exposure for five or ten weeks did not affect the ovarian endpoints examined herein.

Comments

This is a manuscript of an article published as Ganesan, Shanthi, Bailey C. McGuire, and Aileen F. Keating. "Absence of glyphosate-induced effects on ovarian folliculogenesis and steroidogenesis." Reproductive Toxicology (2020). doi: 10.1016/j.reprotox.2020.06.011. Posted with permission.

Description
Keywords
Citation
DOI
Copyright
Wed Jan 01 00:00:00 UTC 2020
Collections