Comparison of the Cardiovascular Benefits of Resistance, Aerobic, and Combined Exercise (CardioRACE): Rationale, design, and methods

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dc.contributor.author Brellenthin, Angelique
dc.contributor.author Lanningham-Foster, Lorraine
dc.contributor.author Kohut, Marian
dc.contributor.author Lee, Duck-Chul
dc.contributor.author Li, Yehua
dc.contributor.author Church, Timothy
dc.contributor.author Blair, Steven
dc.contributor.author Lee, Duck-Chul
dc.contributor.department Food Science and Human Nutrition
dc.contributor.department Kinesiology
dc.date 2021-01-05T04:06:08.000
dc.date.accessioned 2021-02-26T02:28:49Z
dc.date.available 2021-02-26T02:28:49Z
dc.date.copyright Mon Jan 01 00:00:00 UTC 2018
dc.date.issued 2019-11-01
dc.description.abstract <p>Background The benefits of aerobic exercise (AE) for cardiovascular disease (CVD) have been well documented. Resistance exercise (RE) has been traditionally examined for its effects on bone density, physical function, or metabolic health, yet few data exist regarding the benefits of RE, independent of and combined with AE, for CVD prevention. This randomized controlled trial, “Comparison of the Cardiovascular Benefits of Resistance, Aerobic, and Combined Exercise (CardioRACE),” is designed to determine the relative benefits of RE, AE, or combined RE plus AE training on CVD risk factors.</p> <p>Methods Participants are 406 inactive men and women (35-70 years) with a body mass index of 25-40 kg/m2 and blood pressure (BP) of 120-139/80-89 mm Hg without taking antihypertensive medications. Participants are randomly assigned to RE only, AE only, combined RE and AE (CE), or a no exercise control group. Participants perform supervised exercise at 50%-80% of their relative maximum intensity for both AE and RE, 3 times a week for 60 minutes per session, for 1 year (all 3 groups are time matched).</p> <p>Results The primary outcome is a composite z score including resting BP, low-density lipoprotein cholesterol (LDL-C), fasting glucose, and percent body fat, which is assessed at baseline, 6 months, and 12 months. Diet and outside physical activity are measured throughout the intervention for 1 year.</p> <p>Conclusion CardioRACE (ClinicalTrials.gov NCT03069092) will fill an important knowledge gap regarding the effects of RE, alone or in addition to the well-documented effects of AE. CardioRACE will help generate more comprehensive and synergistic clinical and public health strategies to prevent CVD.</p>
dc.description.comments <p>This accepted article is published as 94. Brellenthin AG, Lanningham-Foster LM, Kohut ML, Li Y, Church TS, Blair SN, Lee DC (corresponding author). Comparison of the cardiovascular benefits of resistance, aerobic, and combined exercise (CardioRACE): rationale, design, and methods. Am Heart J. 217(2019); 101-111. doi: <a target="_blank">10.1016/j.ahj.2019.08.008</a>. Posted with permission.</p>
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dc.identifier archive/lib.dr.iastate.edu/kin_pubs/78/
dc.identifier.articleid 1079
dc.identifier.contextkey 20929076
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath kin_pubs/78
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/96546
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/kin_pubs/78/2019_LeeDC_MANU___Comparison_of_the_Cardiovascular_Benefits.pdf|||Sat Jan 15 01:54:26 UTC 2022
dc.source.uri 10.1016/j.ahj.2019.08.008
dc.subject.disciplines Cardiovascular Diseases
dc.subject.disciplines Exercise Science
dc.subject.disciplines Kinesiology
dc.subject.disciplines Psychology of Movement
dc.title Comparison of the Cardiovascular Benefits of Resistance, Aerobic, and Combined Exercise (CardioRACE): Rationale, design, and methods
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 4b9a255a-7593-4589-b7fa-5bdb5817d9d7
relation.isOrgUnitOfPublication 4b6428c6-1fda-4a40-b375-456d49d2fb80
relation.isOrgUnitOfPublication f7b0f2ca-8e43-4084-8a10-75f62e5199dd
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