The Genetic Immunodeficiency Disease, Leukocyte Adhesion Deficiency, in Humans, Dogs, Cattle, and Mice

Date
2004-08-01
Authors
Gu, Yu-chen
Bauer, Thomas
Ackermann, Mark
Smith, C.
Kehrli, Marcus
Starost, Matthew
Hickstein, Dennis
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Altmetrics
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Research Projects
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Veterinary Pathology
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Abstract

This review highlights the genotype-phenotype relationship of the genetic immunodeficiency disease leukocyte adhesion deficiency (LAD) in humans, dogs, cattle, and mice, and provides assessment of the opportunities that each animal species provides in the understanding of leukocyte biology and in developing new therapeutic approaches to LAD in humans. This comparison is important since animal models of genetic diseases in humans provide the opportunity to test new therapeutic approaches in an appropriate, disease-specific model. The success of this approach is dependent on the relationship of the phenotype in the animal to the phenotype of the disease in humans.

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This article is from Comparative Medicine 54, no. 4 (August 2004): 363–372.

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