Craniofacial Diseases Caused by Defects in Intracellular Trafficking
Date
2021-05-13
Authors
Lu, Chung-Ling
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MDPI
Abstract
Cells use membrane-bound carriers to transport cargo molecules like membrane proteins and soluble proteins, to their destinations. Many signaling receptors and ligands are synthesized in the endoplasmic reticulum and are transported to their destinations through intracellular trafficking pathways. Some of the signaling molecules play a critical role in craniofacial morphogenesis. Not surprisingly, variants in the genes encoding intracellular trafficking machinery can cause craniofacial diseases. Despite the fundamental importance of the trafficking pathways in craniofacial morphogenesis, relatively less emphasis is placed on this topic, thus far. Here, we describe craniofacial diseases caused by lesions in the intracellular trafficking machinery and possible treatment strategies for such diseases.
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This article is published as Lu, Chung-Ling, and Jinoh Kim. "Craniofacial diseases caused by defects in intracellular trafficking." Genes 12, no. 5 (2021): 726.
DOI: 10.3390/genes12050726.
Copyright 2021 by the authors.
Attribution 4.0 International (CC BY 4.0).
Posted with permission.