Design frameworks can be helpful in the development of complex systems needed to automate machines. Designing autonomous off-road machinery requires having the means for managing the complexity of multiple interacting systems. A design framework, consisting of four technical layers, is presented. These layers are (1) machine architecture, (2) machine awareness, (3) machine control, and (4) machine behavior. Examples of technology advanced in development efforts of autonomous, robotic platforms for agricultural applications are provided. Linkages were made to applications in the construction machinery sector. Similarities between agricultural and construction automation exist in each of the technical layers.