Our lameness research team at Iowa State University, comprised of faculty members Drs. Paul Plummer, Pat Gorden and Jan Shearer, and graduate students Drs. Adam Krull and John Coatney, has been actively studying digital dermatitis for the past six years. Our work has been focused on identifying causative agents for the purpose of developing better strategies for its treatment and control. In the following article, we review current understanding of this disease and highlight some of our research findings.